Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

Hypertension
Authors
Keywords
Abstract

Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular disease later in life. We have sequenced 124 candidate genes implicated in preeclampsia to pinpoint genetic variants contributing to predisposition to or protection from preeclampsia. First, targeted exomic sequencing was performed in 500 preeclamptic women and 190 controls from the FINNPEC cohort (Finnish Genetics of Preeclampsia Consortium). Then 122 women with a history of preeclampsia and 1905 parous women with no such history from the National FINRISK Study (a large Finnish population survey on risk factors of chronic, noncommunicable diseases) were included in the analyses. We tested 146 rare and low-frequency variants and found an excess (observed 13 versus expected 7.3) nominally associated with preeclampsia (

Year of Publication
2017
Journal
Hypertension
Volume
70
Issue
2
Pages
365-371
Date Published
2017 08
ISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.117.09406
PubMed ID
28652462
PubMed Central ID
PMC5535812
Links
Grant list
F30 HL103072 / HL / NHLBI NIH HHS / United States
P30 AR048335 / AR / NIAMS NIH HHS / United States
R01 GM099111 / GM / NIGMS NIH HHS / United States
U54 HL112303 / HL / NHLBI NIH HHS / United States