The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.
Nat Commun
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Abstract | Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q |
Year of Publication | 2017
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Journal | Nat Commun
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Volume | 8
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Issue | 1
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Pages | 2185
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Date Published | 2017 12 19
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ISSN | 2041-1723
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DOI | 10.1038/s41467-017-02329-y
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PubMed ID | 29259203
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PubMed Central ID | PMC5736707
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Grant list | U10 CA180861 / CA / NCI NIH HHS / United States
R01 CA182461 / CA / NCI NIH HHS / United States
R01 HL131768 / HL / NHLBI NIH HHS / United States
R01 CA216273 / CA / NCI NIH HHS / United States
K01 ES025431 / ES / NIEHS NIH HHS / United States
P01 CA206978 / CA / NCI NIH HHS / United States
R01 HL116452 / HL / NHLBI NIH HHS / United States
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