The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.

Nat Commun
Authors
Keywords
Abstract

Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q 

Year of Publication
2017
Journal
Nat Commun
Volume
8
Issue
1
Pages
2185
Date Published
2017 12 19
ISSN
2041-1723
DOI
10.1038/s41467-017-02329-y
PubMed ID
29259203
PubMed Central ID
PMC5736707
Links
Grant list
U10 CA180861 / CA / NCI NIH HHS / United States
R01 CA182461 / CA / NCI NIH HHS / United States
R01 HL131768 / HL / NHLBI NIH HHS / United States
R01 CA216273 / CA / NCI NIH HHS / United States
K01 ES025431 / ES / NIEHS NIH HHS / United States
P01 CA206978 / CA / NCI NIH HHS / United States
R01 HL116452 / HL / NHLBI NIH HHS / United States