Samarium Barbier reactions of alpha-iodomethyloxazoles and thiazoles with aliphatic aldehydes.

Org Lett

Authors	David Williams Martin Berliner Bryan Stroup Partha Nag Michael Clark
Keywords	Molecular Structure Aldehydes Oxazoles Heterocyclic Compounds, 4 or More Rings Thiazoles Methylation Iodine Samarium
Abstract	[reaction: see text] The reductive coupling of substituted alpha-iodomethyloxazoles and thiazoles with aliphatic aldehydes under Barbier conditions provides an effective method for the direct incorporation of intact heterocyclic systems.
Year of Publication	2005
Journal	Org Lett
Volume	7
Issue	19
Pages	4099-102
Date Published	2005 Sep 15
ISSN	1523-7060
DOI	10.1021/ol051345v
PubMed ID	16146361
Links	PubMed DOI Google Scholar
Grant list	GM-41560 / GM / NIGMS NIH HHS / United States

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