Transmembrane channels based on tartaric acid-gramicidin A hybrids.

Science
Authors
Keywords
Abstract

The gramicidin A transmembrane channel is believed to consist of two head-to-head beta helices. Computer-generated models were used to formulate the structure of new single-chain channel molecules based on the gramicidin motif. The chemical synthesis of two tartaric acid-gramicidin A hybrids and single-channel analyses of their conducting properties are reported. These studies illustrate the rational design and synthesis of long-lived channels with tunable conductance properties and provide support for current molecular models of the natural (dimeric) gramicidin channel.

Year of Publication
1989
Journal
Science
Volume
244
Issue
4906
Pages
813-7
Date Published
1989 May 19
ISSN
0036-8075
PubMed ID
2471263
Links
Grant list
NS-21501 / NS / NINDS NIH HHS / United States