Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen.

Antimicrob Agents Chemother
Authors
Lee Peng
Sun Kim
Sirinya Matchacheep
Xiaoguang Lei
Shun Su
Wenyu Lin
Weerawat Runguphan
Won-Hyeok Choe
Naoya Sakamoto
Masanori Ikeda
Nobuyuki Kato
Aaron Beeler
John Porco
Stuart Schreiber
Raymond Chung
Keywords
Reproducibility of Results
Computer Simulation
Drug Design
Structure-Activity Relationship
Epoxy Compounds
Hepacivirus
Drug Evaluation, Preclinical
Virus Replication
Maleimides
Antiviral Agents
Cytopathogenic Effect, Viral
Replicon
Abstract

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration,

Year of Publication
2007
Journal
Antimicrob Agents Chemother
Volume
51
Issue
10
Pages
3756-9
Date Published
2007 Oct
ISSN
0066-4804
DOI
10.1128/AAC.00233-07
PubMed ID
17682098
PubMed Central ID
PMC2043288
Links
Grant list
K08 DK088951 / DK / NIDDK NIH HHS / United States
T32 DK007191 / DK / NIDDK NIH HHS / United States
P50 GM067041 / GM / NIGMS NIH HHS / United States
NS050854-01 / NS / NINDS NIH HHS / United States
R03 NS050854 / NS / NINDS NIH HHS / United States
5 T32 DK07191-31 / DK / NIDDK NIH HHS / United States
N01 CO12400 / CO / NCI NIH HHS / United States
N01CO12400 / CA / NCI NIH HHS / United States

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