ChemBank: a small-molecule screening and cheminformatics resource database.

Nucleic Acids Res
Authors
Keywords
Abstract

ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector.

Year of Publication
2008
Journal
Nucleic Acids Res
Volume
36
Issue
Database issue
Pages
D351-9
Date Published
2008 Jan
ISSN
1362-4962
DOI
10.1093/nar/gkm843
PubMed ID
17947324
PubMed Central ID
PMC2238881
Links
Grant list
P50-GM069721 / GM / NIGMS NIH HHS / United States
P20-HG003895 / HG / NHGRI NIH HHS / United States
P50 GM069721 / GM / NIGMS NIH HHS / United States
N01CO12400 / CA / NCI NIH HHS / United States
N01-CO-12400 / CO / NCI NIH HHS / United States
P20 HG003895 / HG / NHGRI NIH HHS / United States