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Nucleic Acids Res DOI:10.1093/nar/gkm843

ChemBank: a small-molecule screening and cheminformatics resource database.

Publication TypeJournal Article
Year of Publication2008
AuthorsSeiler, KPetri, George, GA, Happ, MPat, Bodycombe, NE, Carrinski, HA, Norton, S, Brudz, S, Sullivan, JP, Muhlich, J, Serrano, M, Ferraiolo, P, Tolliday, NJ, Schreiber, SL, Clemons, PA
JournalNucleic Acids Res
Volume36
IssueDatabase issue
PagesD351-9
Date Published2008 Jan
ISSN1362-4962
KeywordsBiological Assay, Cell Line, Chemical Phenomena, Chemistry, Computational Biology, Computer Graphics, Databases, Factual, Drug Evaluation, Preclinical, Internet, Pharmaceutical Preparations, Software, User-Computer Interface
Abstract

ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment includes freely available data derived from small molecules and small-molecule screens and resources for studying these data. ChemBank is unique among small-molecule databases in its dedication to the storage of raw screening data, its rigorous definition of screening experiments in terms of statistical hypothesis testing, and its metadata-based organization of screening experiments into projects involving collections of related assays. ChemBank stores an increasingly varied set of measurements derived from cells and other biological assay systems treated with small molecules. Analysis tools are available and are continuously being developed that allow the relationships between small molecules, cell measurements, and cell states to be studied. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the Broad Institute by collaborators from the worldwide research community. The goal of ChemBank is to provide life scientists unfettered access to biomedically relevant data and tools heretofore available primarily in the private sector.

DOI10.1093/nar/gkm843
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17947324?dopt=Abstract

Alternate JournalNucleic Acids Res.
PubMed ID17947324
PubMed Central IDPMC2238881
Grant ListP50-GM069721 / GM / NIGMS NIH HHS / United States
P20-HG003895 / HG / NHGRI NIH HHS / United States
P50 GM069721 / GM / NIGMS NIH HHS / United States
N01CO12400 / CA / NCI NIH HHS / United States
N01-CO-12400 / CO / NCI NIH HHS / United States
P20 HG003895 / HG / NHGRI NIH HHS / United States