Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

Proc Natl Acad Sci U S A
Authors
Keywords
Abstract

Extracellular growth and differentiation factors induce changes in gene expression in the nucleus by initiating a series of protein associations that alter the subcellular localization of intracellular signaling proteins. Initial events involve receptor homo- or heterodimerization and subsequent recruitment of cytosolic signaling proteins to the inner leaflet of the plasma membrane. Intermediate events involve the translocation of proteins into the nucleus. Late events involve the recruitment of transcriptional activators to the vicinity of specific genes in the nucleus, resulting in increased gene transcription. The ability to induce signals at each of these three phases of signaling pathways is illustrated by the use of a heterodimeric chemical inducer of dimerization that causes a proximal relationship between two different target proteins.

Year of Publication
1996
Journal
Proc Natl Acad Sci U S A
Volume
93
Issue
10
Pages
4604-7
Date Published
1996 May 14
ISSN
0027-8424
PubMed ID
8643450
PubMed Central ID
PMC39324
Links
Grant list
CA39612 / CA / NCI NIH HHS / United States
GM52067 / GM / NIGMS NIH HHS / United States