Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.
J Am Chem Soc
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Abstract | Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles. |
Year of Publication | 2011
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Journal | J Am Chem Soc
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Volume | 133
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Issue | 24
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Pages | 9196-9
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Date Published | 2011 Jun 22
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ISSN | 1520-5126
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DOI | 10.1021/ja202012s
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PubMed ID | 21557625
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Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
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