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Bioorg Med Chem Lett DOI:10.1016/j.bmcl.2012.02.035

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Publication TypeJournal Article
Year of Publication2012
AuthorsYoungsaye, W, Dockendorff, C, Vincent, B, Hartland, CL, Bittker, JA, Dandapani, S, Palmer, M, Whitesell, L, Lindquist, S, Schreiber, SL, Munoz, B
JournalBioorg Med Chem Lett
Volume22
Issue9
Pages3362-5
Date Published2012 May 01
ISSN1464-3405
KeywordsCandida albicans, Drug Resistance, Fungal, Fluconazole, Indoles, Signal Transduction
Abstract

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.

DOI10.1016/j.bmcl.2012.02.035
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22497765?dopt=Abstract

Alternate JournalBioorg. Med. Chem. Lett.
PubMed ID22497765
PubMed Central IDPMC3386803
Grant ListR03 MH086456 / MH / NIMH NIH HHS / United States
U54 HG005032 / HG / NHGRI NIH HHS / United States
1 R03 MH086456-01 / MH / NIMH NIH HHS / United States
1 U54 HG005032-1 / HG / NHGRI NIH HHS / United States