Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Bioorg Med Chem Lett

Authors	Willmen Youngsaye Chris Dockendorff Benjamin Vincent Cathy Hartland Joshua Bittker Sivaraman Dandapani Michelle Palmer Luke Whitesell Susan Lindquist Stuart Schreiber Benito Munoz
Keywords	Signal Transduction Candida albicans Indoles Drug Resistance, Fungal Fluconazole
Abstract	Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
Year of Publication	2012
Journal	Bioorg Med Chem Lett
Volume	22
Issue	9
Pages	3362-5
Date Published	2012 May 01
ISSN	1464-3405
DOI	10.1016/j.bmcl.2012.02.035
PubMed ID	22497765
PubMed Central ID	PMC3386803
Links	Google Scholar PubMed DOI
Grant list	R03 MH086456 / MH / NIMH NIH HHS / United States U54 HG005032 / HG / NHGRI NIH HHS / United States 1 R03 MH086456-01 / MH / NIMH NIH HHS / United States 1 U54 HG005032-1 / HG / NHGRI NIH HHS / United States