Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
|Year of Publication||
Bioorg Med Chem Lett
2012 May 01
|PubMed Central ID||
R03 MH086456 / MH / NIMH NIH HHS / United States
U54 HG005032 / HG / NHGRI NIH HHS / United States
1 R03 MH086456-01 / MH / NIMH NIH HHS / United States
1 U54 HG005032-1 / HG / NHGRI NIH HHS / United States