ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.

Beilstein J Org Chem
Publication type
Journal Article
Authors
Abstract

The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.

Year of Publication
2013
Journal
Beilstein J Org Chem
Volume
9
Pages
1501-7
Date Published
2013
ISSN
1860-5397
DOI
10.3762/bjoc.9.171
PubMed ID
23946849
PubMed Central ID
PMC3740683
Links
Grant list
R03 MH086456 / MH / NIMH NIH HHS / United States
U54 HG005032 / HG / NHGRI NIH HHS / United States