Chemistry and biology of the immunophilins and their immunosuppressive ligands.

Science
Authors
Keywords
Abstract

Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.

Year of Publication
1991
Journal
Science
Volume
251
Issue
4991
Pages
283-7
Date Published
1991 Jan 18
ISSN
0036-8075
PubMed ID
1702904
Links
Grant list
GM-38627 / GM / NIGMS NIH HHS / United States