Characterising -regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.

Gut
Authors
Keywords
Abstract

OBJECTIVE: To elucidate the genetic architecture of gene expression in pancreatic tissues.

DESIGN: We performed expression quantitative trait locus (eQTL) analysis in histologically normal pancreatic tissue samples (n=95) using RNA sequencing and the corresponding 1000 genomes imputed germline genotypes. Data from pancreatic tumour-derived tissue samples (n=115) from The Cancer Genome Atlas were included for comparison.

RESULTS: We identified 38 615 -eQTLs (in 484 genes) in histologically normal tissues and 39 713 -eQTL (in 237 genes) in tumour-derived tissues (false discovery rate

CONCLUSIONS: We have identified -eQTLs representing potential functional regulatory variants in the pancreas and generated a rich data set for further studies on gene expression and its regulation in pancreatic tissues.

Year of Publication
2018
Journal
Gut
Volume
67
Issue
3
Pages
521-533
Date Published
2018 03
ISSN
1468-3288
DOI
10.1136/gutjnl-2016-313146
PubMed ID
28634199
PubMed Central ID
PMC5762429
Links
Grant list
ZIA CP010193-06 / NULL / Intramural NIH HHS / United States
ZIA CP010193-05 / ImNIH / Intramural NIH HHS / United States
ZIA CP010193-09 / NULL / Intramural NIH HHS / United States
Z99 CA999999 / ImNIH / Intramural NIH HHS / United States
ZIA CP010193-09 / ImNIH / Intramural NIH HHS / United States
ZIA CP010193-7 / ImNIH / Intramural NIH HHS / United States
R01 DA006227 / DA / NIDA NIH HHS / United States
Z99 CA999999 / NULL / Intramural NIH HHS / United States
R01 MH101782 / MH / NIMH NIH HHS / United States
R01 MH101810 / MH / NIMH NIH HHS / United States
R01 MH101819 / MH / NIMH NIH HHS / United States
ZIA CP010193-05 / NULL / Intramural NIH HHS / United States
R01 MH090936 / MH / NIMH NIH HHS / United States
ZIA CP010193-07 / NULL / Intramural NIH HHS / United States
U01 DK105535 / DK / NIDDK NIH HHS / United States
ZIA CP010193-06 / ImNIH / Intramural NIH HHS / United States
ZIA CP010193-10 / ImNIH / Intramural NIH HHS / United States
P50 CA102701 / CA / NCI NIH HHS / United States
ZIA CP010193-08 / ImNIH / Intramural NIH HHS / United States
ZIA CP010193-07 / ImNIH / Intramural NIH HHS / United States
R01 MH090951 / MH / NIMH NIH HHS / United States
ZIA CP010193-7 / NULL / Intramural NIH HHS / United States
R01 MH101820 / MH / NIMH NIH HHS / United States
R01 MH101825 / MH / NIMH NIH HHS / United States
R01 MH090948 / MH / NIMH NIH HHS / United States
R01 MH090941 / MH / NIMH NIH HHS / United States
Wellcome Trust / United Kingdom
ZIA CP010193-08 / NULL / Intramural NIH HHS / United States
R01 MH101822 / MH / NIMH NIH HHS / United States
HHSN261200800001C / RC / CCR NIH HHS / United States
R01 MH090937 / MH / NIMH NIH HHS / United States
ZIA CP010193-10 / NULL / Intramural NIH HHS / United States
HHSN268201000029C / HL / NHLBI NIH HHS / United States
HHSN261200800001E / CA / NCI NIH HHS / United States
R01 MH101814 / MH / NIMH NIH HHS / United States