Fiber-derived butyrate and the prevention of colon cancer.

Chem Biol
Authors
Keywords
Abstract

Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.

Year of Publication
1997
Journal
Chem Biol
Volume
4
Issue
11
Pages
783-9
Date Published
1997 Nov
ISSN
1074-5521
PubMed ID
9384528
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