Fiber-derived butyrate and the prevention of colon cancer.
Chem Biol
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Abstract | Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate. |
Year of Publication | 1997
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Journal | Chem Biol
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Volume | 4
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Issue | 11
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Pages | 783-9
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Date Published | 1997 Nov
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ISSN | 1074-5521
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PubMed ID | 9384528
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