Macrocycloadditions leading to conformationally restricted small molecules.

Org Lett

Authors	Ryan Looper Daniela Pizzirani Stuart Schreiber
Keywords	Macrocyclic Compounds Molecular Structure Alkynes Catalysis Cyclization Stereoisomerism Azides Molecular Conformation Copper Triazoles
Abstract	[reaction: see text] The Cu(I)-catalyzed cycloaddition of alkynes and azides (click reaction) provides a robust method for the construction of macrocyclic small molecules via an intramolecular macrocycloaddition. A three-subunit system has been used to explore the tolerance of this macrocycloaddition to variations of stereochemistries and substituents.
Year of Publication	2006
Journal	Org Lett
Volume	8
Issue	10
Pages	2063-6
Date Published	2006 May 11
ISSN	1523-7060
DOI	10.1021/ol0604724
PubMed ID	16671782
Links	Google Scholar PubMed DOI

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