Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

Org Lett
Authors
Keywords
Abstract

A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

Year of Publication
2009
Journal
Org Lett
Volume
11
Issue
22
Pages
5178-80
Date Published
2009 Nov 19
ISSN
1523-7052
DOI
10.1021/ol902079g
PubMed ID
19860425
PubMed Central ID
PMC2776381
Links
Grant list
P01 CA078048 / CA / NCI NIH HHS / United States
P01-CA078048 / CA / NCI NIH HHS / United States
Howard Hughes Medical Institute / United States