Stereochemical and skeletal diversity arising from amino propargylic alcohols.

Org Lett
Authors
Daniela Pizzirani
Taner Kaya
Paul Clemons
Stuart Schreiber
Keywords
Molecular Structure
Cyclization
Stereoisomerism
Amino Alcohols
Heterocyclic Compounds, 4 or More Rings
Abstract

An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.
Year of Publication
2010
Journal
Org Lett
Volume
12
Issue
12
Pages
2822-5
Date Published
2010 Jun 18
ISSN
1523-7052
DOI
10.1021/ol100914b
PubMed ID
20481457
PubMed Central ID
PMC2883853
Links
Grant list
P50 GM069721 / GM / NIGMS NIH HHS / United States
P50-GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States

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