Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.

Org Lett
Authors
Keywords
Abstract

A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is quantified and compared using principal moment-of-inertia shape analysis.

Year of Publication
2010
Journal
Org Lett
Volume
12
Issue
22
Pages
5230-3
Date Published
2010 Nov 19
ISSN
1523-7052
DOI
10.1021/ol102266j
PubMed ID
20977261
PubMed Central ID
PMC2979010
Links
Grant list
P50 GM069721 / GM / NIGMS NIH HHS / United States
P50-GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States