Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.
Org Lett
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Abstract | A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is quantified and compared using principal moment-of-inertia shape analysis. |
Year of Publication | 2010
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Journal | Org Lett
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Volume | 12
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Issue | 22
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Pages | 5230-3
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Date Published | 2010 Nov 19
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ISSN | 1523-7052
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DOI | 10.1021/ol102266j
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PubMed ID | 20977261
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PubMed Central ID | PMC2979010
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Grant list | P50 GM069721 / GM / NIGMS NIH HHS / United States
P50-GM069721 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
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