Solving chemical problems through the application of evolutionary principles.

Curr Opin Chem Biol
Authors
Keywords
Abstract

Molecular evolution has been widely applied in the laboratory to generate novel biological macromolecules. The principles underlying evolution have more recently been used to address problems in the chemical sciences, including the discovery of functional synthetic small molecules, catalysts, materials and new chemical reactions. The application of these principles in dynamic combinatorial chemistry and in efforts involving small molecule-nucleic acid conjugates has facilitated the evaluation of large numbers of candidate structures or reactions for desired characteristics. These early efforts suggest the promise of pairing evolutionary approaches with synthetic chemistry.

Year of Publication
2007
Journal
Curr Opin Chem Biol
Volume
11
Issue
3
Pages
259-68
Date Published
2007 Jun
ISSN
1367-5931
DOI
10.1016/j.cbpa.2007.05.016
PubMed ID
17548235
Links
Grant list
R01 GM065865 / GM / NIGMS NIH HHS / United States