A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.
Chem Biol
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Abstract | We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions. |
Year of Publication | 2011
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Journal | Chem Biol
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Volume | 18
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Issue | 7
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Pages | 833-8
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Date Published | 2011 Jul 29
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ISSN | 1879-1301
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DOI | 10.1016/j.chembiol.2011.07.003
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PubMed ID | 21802004
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PubMed Central ID | PMC3154086
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Links | |
Grant list | R01 GM065400-02 / GM / NIGMS NIH HHS / United States
R01 GM095501-02 / GM / NIGMS NIH HHS / United States
R01GM065400 / GM / NIGMS NIH HHS / United States
R01 GM095501-01 / GM / NIGMS NIH HHS / United States
R01 GM065400-06 / GM / NIGMS NIH HHS / United States
R01 GM065400-01 / GM / NIGMS NIH HHS / United States
U01 DK089536 / DK / NIDDK NIH HHS / United States
R01 GM065400-09 / GM / NIGMS NIH HHS / United States
R01 GM065400-04 / GM / NIGMS NIH HHS / United States
Howard Hughes Medical Institute / United States
R01 GM065400 / GM / NIGMS NIH HHS / United States
R01 GM065400-08 / GM / NIGMS NIH HHS / United States
R01 GM065400-03 / GM / NIGMS NIH HHS / United States
R01 GM065400-05 / GM / NIGMS NIH HHS / United States
DK089536 / DK / NIDDK NIH HHS / United States
R01 GM095501 / GM / NIGMS NIH HHS / United States
R01 GM065400-07 / GM / NIGMS NIH HHS / United States
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