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Sci Rep DOI:10.1038/s41598-017-16011-2

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Publication TypeJournal Article
Year of Publication2017
AuthorsHuang, H, Duggal, P, Thio, CL, Latanich, R, Goedert, JJ, Mangia, A, Cox, AL, Kirk, GD, Mehta, S, Aneja, J, Alric, L, Donfield, SM, Cramp, ME, Khakoo, SI, Tobler, LH, Busch, M, Alexander, GJ, Rosen, HR, Edlin, BR, Segal, FP, Lauer, GM, Thomas, DL, Daly, MJ, Chung, RT, Kim, AY
JournalSci Rep
Volume7
Issue1
Pages15843
Date Published2017 Nov 20
ISSN2045-2322
Abstract

Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.

DOI10.1038/s41598-017-16011-2
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/29158528?dopt=Abstract

Alternate JournalSci Rep
PubMed ID29158528
PubMed Central IDPMC5696522
Grant ListU01 AI035042 / AI / NIAID NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 DA033541 / DA / NIDA NIH HHS / United States
UL1 RR024996 / RR / NCRR NIH HHS / United States
R01 DA013324 / DA / NIDA NIH HHS / United States
K01 DK114379 / DK / NIDDK NIH HHS / United States
R01 DA021550 / DA / NIDA NIH HHS / United States
R01 DA004334 / DA / NIDA NIH HHS / United States
U01 AI035041 / AI / NIAID NIH HHS / United States
R01 DA016159 / DA / NIDA NIH HHS / United States
U19 AI082630 / AI / NIAID NIH HHS / United States
UM1 AI035043 / AI / NIAID NIH HHS / United States
R01 HL076902 / HL / NHLBI NIH HHS / United States
R01 HD041224 / HD / NICHD NIH HHS / United States
UL1 TR002384 / TR / NCATS NIH HHS / United States
U01 AI035043 / AI / NIAID NIH HHS / United States
R01 DA012568 / DA / NIDA NIH HHS / United States
U01 AI035040 / AI / NIAID NIH HHS / United States
U01 AI035039 / AI / NIAID NIH HHS / United States
G1001738 / / Medical Research Council / United Kingdom
U19 AI088791 / AI / NIAID NIH HHS / United States