Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.
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Abstract | Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe. |
Year of Publication | 2017
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Journal | Sci Rep
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Volume | 7
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Issue | 1
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Pages | 15843
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Date Published | 2017 Nov 20
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ISSN | 2045-2322
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DOI | 10.1038/s41598-017-16011-2
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PubMed ID | 29158528
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PubMed Central ID | PMC5696522
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Grant list | U01 AI035042 / AI / NIAID NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 DA013324 / DA / NIDA NIH HHS / United States
K01 DK114379 / DK / NIDDK NIH HHS / United States
R01 HL076902 / HL / NHLBI NIH HHS / United States
R01 HD041224 / HD / NICHD NIH HHS / United States
UL1 TR002384 / TR / NCATS NIH HHS / United States
U01 AI035043 / AI / NIAID NIH HHS / United States
R01 DA012568 / DA / NIDA NIH HHS / United States
U01 AI035040 / AI / NIAID NIH HHS / United States
U01 AI035039 / AI / NIAID NIH HHS / United States
U19 AI088791 / AI / NIAID NIH HHS / United States
R01 DA033541 / DA / NIDA NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
UL1 RR024996 / RR / NCRR NIH HHS / United States
R01 DA021550 / DA / NIDA NIH HHS / United States
R01 DA004334 / DA / NIDA NIH HHS / United States
U01 AI035041 / AI / NIAID NIH HHS / United States
R01 DA016159 / DA / NIDA NIH HHS / United States
U19 AI082630 / AI / NIAID NIH HHS / United States
UM1 AI035043 / AI / NIAID NIH HHS / United States
MR/M019829/1 / MRC_ / Medical Research Council / United Kingdom
G1001738 / MRC_ / Medical Research Council / United Kingdom
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