|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Huang, H, Duggal, P, Thio, CL, Latanich, R, Goedert, JJ, Mangia, A, Cox, AL, Kirk, GD, Mehta, S, Aneja, J, Alric, L, Donfield, SM, Cramp, ME, Khakoo, SI, Tobler, LH, Busch, M, Alexander, GJ, Rosen, HR, Edlin, BR, Segal, FP, Lauer, GM, Thomas, DL, Daly, MJ, Chung, RT, Kim, AY|
|Date Published||2017 Nov 20|
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.
|Alternate Journal||Sci Rep|