A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.
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Abstract | BACKGROUND: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. METHODS: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. RESULTS: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WC; R = -0.079, P CONCLUSIONS: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors. |
Year of Publication | 2017
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Journal | Genome Med
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Volume | 9
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Issue | 1
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Pages | 99
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Date Published | 2017 Nov 27
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ISSN | 1756-994X
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DOI | 10.1186/s13073-017-0491-4
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PubMed ID | 29178946
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PubMed Central ID | PMC5702961
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Grant list | UL1 TR001863 / TR / NCATS NIH HHS / United States
R01 MH106595 / National Institute of Mental Health
U01 MH109536 / MH / NIMH NIH HHS / United States
U01 MH109514 / MH / NIMH NIH HHS / United States
National Center for PTSD Research / U.S. Department of Veterans Affairs
U01 MH109532 / MH / NIMH NIH HHS / United States
R01 MH106595 / MH / NIMH NIH HHS / United States
U01 MH109532 / National Institute of Mental Health
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