|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Polimanti, R, Amstadter, AB, Stein, MB, Almli, LM, Baker, DG, Bierut, LJ, Bradley, B, Farrer, LA, Johnson, EO, King, A, Kranzler, HR, Maihofer, AX, Rice, JP, Roberts, AL, Saccone, NL, Zhao, H, Liberzon, I, Ressler, KJ, Nievergelt, CM, Koenen, KC, Gelernter, J|
|Corporate Authors||Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup|
|Date Published||2017 Nov 27|
BACKGROUND: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear.
METHODS: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships.
RESULTS: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P
CONCLUSIONS: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors.
|Alternate Journal||Genome Med|
|Grant List||R01 MH106595 / / National Institute of Mental Health / United States |
U01 MH109532 / / National Institute of Mental Health / United States
National Center for PTSD Research / / U.S. Department of Veterans Affairs / United States