Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.
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Abstract | Over the past decade, tremendous progress in high-throughput small molecule-screening methods has facilitated the rapid expansion of phenotype-based data. Parallel advances in genomic characterization methods have complemented these efforts by providing a growing list of annotated cell line features. Together, these developments have paved the way for feature-based identification of novel, exploitable cellular dependencies, subsequently expanding our therapeutic toolkit in cancer and other diseases. Here, we provide an overview of the evolution of phenotypic small-molecule profiling and discuss the most significant and recent profiling and analytical efforts, their impact on the field, and their clinical ramifications. We additionally provide a perspective for future developments in phenotypic profiling efforts guided by genomic science. |
Year of Publication | 2015
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Journal | Trends Genet
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Volume | 31
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Issue | 1
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Pages | 16-23
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Date Published | 2015 Jan
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ISSN | 0168-9525
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DOI | 10.1016/j.tig.2014.11.002
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PubMed ID | 25498789
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PubMed Central ID | PMC4281276
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Grant list | RC2 CA148399 / CA / NCI NIH HHS / United States
RC2-CA148399 / CA / NCI NIH HHS / United States
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