|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Coleman, JJ, Komura, T, Munro, J, Wu, MP, Busanelli, RR, Koehler, AN, Thomas, M, Wagner, FF, Holson, EB, Mylonakis, E|
|Journal||Future Med Chem|
|Date Published||2016 Oct 14|
AIM: Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.
RESULTS: CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens.
CONCLUSION: Caenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds.
|Alternate Journal||Future Med Chem|
|Grant List||P01 AI083214 / AI / NIAID NIH HHS / United States|