Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.
Authors | |
Abstract | AIM: Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans. RESULTS: CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens. CONCLUSION: Caenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds. |
Year of Publication | 2016
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Journal | Future Med Chem
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Date Published | 2016 Oct 14
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ISSN | 1756-8927
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DOI | 10.4155/fmc-2016-0085
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PubMed ID | 27739327
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Links | |
Grant list | P01 AI083214 / AI / NIAID NIH HHS / United States
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