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Nat Genet DOI:10.1038/ng.209

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Publication TypeJournal Article
Year of Publication2008
AuthorsFerreira, MAR, O'Donovan, MC, Meng, YA, Jones, IR, Ruderfer, DM, Jones, L, Fan, J, Kirov, G, Perlis, RH, Green, EK, Smoller, JW, Grozeva, D, Stone, J, Nikolov, I, Chambert, K, Hamshere, ML, Nimgaonkar, VL, Moskvina, V, Thase, ME, Caesar, S, Sachs, GS, Franklin, J, Gordon-Smith, K, Ardlie, KG, Gabriel, SB, Fraser, C, Blumenstiel, B, DeFelice, M, Breen, G, Gill, M, Morris, DW, Elkin, A, Muir, WJ, McGhee, KA, Williamson, R, MacIntyre, DJ, MacLean, AW, St, CDavid, Robinson, M, Van Beck, M, Pereira, ACP, Kandaswamy, R, McQuillin, A, Collier, DA, Bass, NJ, Young, AH, Lawrence, J, I Ferrier, N, Anjorin, A, Farmer, A, Curtis, D, Scolnick, EM, McGuffin, P, Daly, MJ, Corvin, AP, Holmans, PA, Blackwood, DH, Gurling, HM, Owen, MJ, Purcell, SM, Sklar, P, Craddock, N
Corporate AuthorsWellcome Trust Case Control Consortium
JournalNat Genet
Volume40
Issue9
Pages1056-8
Date Published2008 Sep
ISSN1061-4036
KeywordsAnkyrins, Bipolar Disorder, Calcium Channels, L-Type, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 15, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Logistic Models, Polymorphism, Single Nucleotide
Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

DOI10.1038/ng.209
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/18711365?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID18711365
PubMed Central IDPMC2703780
Grant ListG0701003 / / Medical Research Council / United Kingdom
G9309834 / / Medical Research Council / United Kingdom
R01 MH062137 / MH / NIMH NIH HHS / United States
082371 / / Wellcome Trust / United Kingdom
077011 / / Wellcome Trust / United Kingdom
MH062137 / MH / NIMH NIH HHS / United States
076113 / / Wellcome Trust / United Kingdom
MH63420 / MH / NIMH NIH HHS / United States
R01 MH067288 / MH / NIMH NIH HHS / United States
G0500791 / / Medical Research Council / United Kingdom
G9623693N / / Medical Research Council / United Kingdom
/ / Chief Scientist Office / United Kingdom
R01 MH063420 / MH / NIMH NIH HHS / United States
N01MH80001 / MH / NIMH NIH HHS / United States
MH067288 / MH / NIMH NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R01 MH063445 / MH / NIMH NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
MH063445 / MH / NIMH NIH HHS / United States