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Am J Med Genet B Neuropsychiatr Genet DOI:10.1002/ajmg.b.31023

Support of association between BRD1 and both schizophrenia and bipolar affective disorder.

Publication TypeJournal Article
Year of Publication2010
AuthorsNyegaard, M, Severinsen, JE, Als, TD, Hedemand, A, Straarup, S, Nordentoft, M, McQuillin, A, Bass, N, Lawrence, J, Thirumalai, S, Pereira, ACP, Kandaswamy, R, Lydall, GJ, Sklar, P, Scolnick, E, Purcell, S, Curtis, D, Gurling, HMD, Mortensen, PB, Mors, O, Børglum, AD
JournalAm J Med Genet B Neuropsychiatr Genet
Volume153B
Issue2
Pages582-591
Date Published2010 Mar 05
ISSN1552-485X
KeywordsAlleles, Bipolar Disorder, Case-Control Studies, Family Health, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genotype, Haplotypes, Humans, Models, Genetic, Nuclear Proteins, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Schizophrenia
Abstract

A recent study published by our group implicated the bromodomain containing protein 1 (BRD1) gene located at chromosome 22q13.33 with schizophrenia (SZ) and bipolar affective disorder (BPD) susceptibility and provided evidence suggesting a possible role for BRD1 in neurodevelopment. The present study reports an association analysis of BRD1 and the neighboring gene ZBED4 using a Caucasian case-control sample from Denmark and England (UK/DK sample: 490 patients with BPD, 527 patients with SZ, and 601 control individuals), and genotypes obtained from a BPD genome wide association (GWA) study of an overlapping English sample comprising 506 patients with BPD and 510 control individuals (UCL sample). In the UK/DK sample we genotyped 11 SNPs in the BRD1 region, of which six showed association with SZ (minimal single marker P-values of 0.0014), including two SNPs that previously showed association in a Scottish population [Severinsen et al. (2006); Mol Psychiatry 11(12): 1126-1138]. Haplotype analysis revealed specific risk as well as protective haplotypes with a minimal P-value of 0.0027. None of the 11 SNPs showed association with BPD. However, analyzing seven BRD1 SNPs obtained from the BPD GWA study, positive associations with BPD was observed with all markers (minimal P-value of 0.0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility.

DOI10.1002/ajmg.b.31023
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19693800?dopt=Abstract

Alternate JournalAm. J. Med. Genet. B Neuropsychiatr. Genet.
PubMed ID19693800
Grant ListG0500791 / / Medical Research Council / United Kingdom
G1000708 / / Medical Research Council / United Kingdom