Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Nat Genet
Authors
Keywords
Abstract

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Year of Publication
2013
Journal
Nat Genet
Volume
45
Issue
9
Pages
984-94
Date Published
2013 Sep
ISSN
1546-1718
DOI
10.1038/ng.2711
PubMed ID
23933821
PubMed Central ID
PMC3800159
Links
Grant list
R01 CA082659 / CA / NCI NIH HHS / United States
P50 HD055782 / HD / NICHD NIH HHS / United States
U01 MH085520 / MH / NIMH NIH HHS / United States
K05 AA017688 / AA / NIAAA NIH HHS / United States
K99 MH101367 / MH / NIMH NIH HHS / United States
G1000632 / Medical Research Council / United Kingdom
R01 MH100027 / MH / NIMH NIH HHS / United States
R01 MH041953 / MH / NIMH NIH HHS / United States
G0800759 / Medical Research Council / United Kingdom
ETM/75 / Chief Scientist Office / United Kingdom
090532 / Wellcome Trust / United Kingdom
G0701420 / Medical Research Council / United Kingdom
CZB/4/540 / Chief Scientist Office / United Kingdom
ETM/137 / Chief Scientist Office / United Kingdom
R01 MH094400 / MH / NIMH NIH HHS / United States
R01 MH083094 / MH / NIMH NIH HHS / United States
G0601030 / Medical Research Council / United Kingdom
R01 MH100141 / MH / NIMH NIH HHS / United States
G1000718 / Medical Research Council / United Kingdom
G0800675 / Medical Research Council / United Kingdom
R25 MH060482 / MH / NIMH NIH HHS / United States
G9810900 / Medical Research Council / United Kingdom
G0600329 / Medical Research Council / United Kingdom