Genetic and activity-dependent mechanisms underlying interneuron diversity.

Nat Rev Neurosci
Publication type
Journal Article
Authors
Keywords
Abstract

The proper construction of neural circuits requires the generation of diverse cell types, their distribution to defined regions, and their specific and appropriate wiring. A major objective in neurobiology has been to understand the molecular determinants that link neural birth to terminal specification and functional connectivity, a task that is especially daunting in the case of cortical interneurons. Considerable evidence supports the idea that an interplay of intrinsic and environmental signalling is crucial to the sequential steps of interneuron specification, including migration, selection of a settling position, morphogenesis and synaptogenesis. However, when and how these influences merge to support the appropriate terminal differentiation of different classes of interneurons remains uncertain. In this Review, we discuss a wealth of recent findings that have advanced our understanding of the developmental mechanisms that contribute to the diversification of interneurons and suggest areas of particular promise for further investigation.

Year of Publication
2017
Journal
Nat Rev Neurosci
Volume
18
Issue
5
Pages
299-309
Date Published
2017 05
ISSN
1471-0048
DOI
10.1038/nrn.2017.30
PubMed ID
28381833
Links
Grant list
P01 NS074972 / NS / NINDS NIH HHS / United States
T32 NS086750 / NS / NINDS NIH HHS / United States