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Brain Res DOI:10.1016/j.brainres.2014.11.032

Microglia function during brain development: New insights from animal models.

Publication TypeJournal Article
Year of Publication2015
AuthorsBilimoria, PM, Stevens, B
JournalBrain Res
Date Published2015 Aug 18
KeywordsAnimals, Apoptosis, Brain, Cell Proliferation, Cell Survival, Humans, Mice, Microglia, Models, Animal, Neurodevelopmental Disorders, Neurons, Synapses

The role of microglia in healthy brains is just beginning to receive notice. Recent studies have revealed that these phagocytic cells control the patterning and wiring of the developing central nervous system (CNS) by regulating, amongst many other processes, programmed cell death, activity-dependent synaptic pruning and synapse maturation. Microglia also play important roles in the mature brain and have demonstrated effects on behavior. Converging evidence from human and mouse studies together raise questions as to the role of microglia in disorders of brain development such as autism and, schizophrenia. In this review, we summarize a number of major findings regarding the role of microglia in brain development and highlight some key questions and avenues for future study. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease.


Alternate JournalBrain Res.
PubMed ID25463024
Grant ListR01NS071008 / NS / NINDS NIH HHS / United States