|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Schafer, DP, Stevens, B|
|Date Published||2015 Apr 21|
|Keywords||Animals, CpG Islands, Epigenesis, Genetic, Female, Humans, Macrophages, Peritoneal, Male, Methyl-CpG-Binding Protein 2, Microglia, Rett Syndrome|
Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.