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Cold Spring Harb Perspect Biol DOI:10.1101/cshperspect.a020545

Microglia Function in Central Nervous System Development and Plasticity.

Publication TypeJournal Article
Year of Publication2015
AuthorsSchafer, DP, Stevens, B
JournalCold Spring Harb Perspect Biol
Date Published2015 Jul 17
KeywordsAnimals, Behavior, Animal, Body Patterning, Cell Death, Cell Differentiation, Cell Proliferation, Cell Survival, Central Nervous System, Disease Models, Animal, Gene Expression Regulation, Developmental, Humans, Macrophages, Mice, Microglia, Models, Neurological, Myeloid Cells, Neuronal Plasticity, Organogenesis, Rats

The nervous system comprises a remarkably diverse and complex network of different cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell populations and their connections with one another pose a rather formidable task. Emerging data implicate microglia, the resident myeloid-derived cells of the central nervous system (CNS), in the spatial patterning and synaptic wiring throughout the healthy, developing, and adult CNS. Importantly, new tools to specifically manipulate microglia function have revealed that these cellular functions translate, on a systems level, to effects on overall behavior. In this review, we give a historical perspective of work to identify microglia function in the healthy CNS and highlight exciting new work in the field that has identified roles for these cells in CNS development, maintenance, and plasticity.


Alternate JournalCold Spring Harb Perspect Biol
PubMed ID26187728
PubMed Central IDPMC4588063
Grant ListF32-NS-066698 / NS / NINDS NIH HHS / United States
K99 MH102351 / MH / NIMH NIH HHS / United States
F32 NS066698 / NS / NINDS NIH HHS / United States
K99-MH-102351 / MH / NIMH NIH HHS / United States
R01-NS-07100801 / NS / NINDS NIH HHS / United States
R01 NS071008 / NS / NINDS NIH HHS / United States