You are here

Trends Immunol DOI:10.1016/

Microglia: Dynamic Mediators of Synapse Development and Plasticity.

Publication TypeJournal Article
Year of Publication2015
AuthorsWu, Y, Dissing-Olesen, L, MacVicar, BA, Stevens, B
JournalTrends Immunol
Date Published2015 Oct
KeywordsAging, Animals, Brain, Central Nervous System, Humans, Inflammation, Microglia, Neuroimmunomodulation, Neuronal Plasticity, Signal Transduction, Synapses

Neuronal communication underlies all brain activity and the genesis of complex behavior. Emerging research has revealed an unexpected role for immune molecules in the development and plasticity of neuronal synapses. Moreover microglia, the resident immune cells of the brain, express and secrete immune-related signaling molecules that alter synaptic transmission and plasticity in the absence of inflammation. When inflammation does occur, microglia modify synaptic connections and synaptic plasticity required for learning and memory. Here we review recent findings demonstrating how the dynamic interactions between neurons and microglia shape the circuitry of the nervous system in the healthy brain and how altered neuron-microglia signaling could contribute to disease.


Alternate JournalTrends Immunol.
PubMed ID26431938
PubMed Central IDPMC4841266
Grant ListR01 NS071008 / NS / NINDS NIH HHS / United States
R01 NS084298 / NS / NINDS NIH HHS / United States