|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Salter, MW, Stevens, B|
|Date Published||2017 Sep 08|
|Keywords||Alzheimer Disease, Animals, Autistic Disorder, Brain Diseases, Cell Death, Central Nervous System Diseases, Chronic Pain, Disease Models, Animal, Humans, Inflammation, Mice, Microglia, Neurodegenerative Diseases, Neurodevelopmental Disorders, Neuronal Plasticity, Phagocytosis|
There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools and mouse models of disease are increasingly implicating this enigmatic type of nervous system cell as a key player in conditions ranging from neurodevelopmental disorders such as autism to neurodegenerative disorders such as Alzheimer's disease and chronic pain. Contemporaneously, diverse roles are emerging for microglia in the healthy brain, from sculpting developing neuronal circuits to guiding learning-associated plasticity. Understanding the physiological functions of these cells is crucial to determining their roles in disease. Here we focus on recent developments in our rapidly expanding understanding of the function, as well as the dysfunction, of microglia in disorders of the CNS.
|Alternate Journal||Nat. Med.|
|Grant List||U54 HD090255 / HD / NICHD NIH HHS / United States|