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Curr Opin Neurobiol DOI:10.1016/j.conb.2011.04.010

Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.

Publication TypeJournal Article
Year of Publication2011
AuthorsTing, JT, Feng, G
JournalCurr Opin Neurobiol
Date Published2011 Dec
KeywordsAnimals, Disease Models, Animal, Humans, Mice, Obsessive-Compulsive Disorder

The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive-repetitive behaviors.


Alternate JournalCurr. Opin. Neurobiol.
PubMed ID21605970
PubMed Central IDPMC3192923
Grant ListR01 MH081201-05 / MH / NIMH NIH HHS / United States
R01MH081201 / MH / NIMH NIH HHS / United States
F32MH084460 / MH / NIMH NIH HHS / United States
R01 MH081201 / MH / NIMH NIH HHS / United States
F32 MH084460 / MH / NIMH NIH HHS / United States