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Nat Neurosci DOI:10.1038/nn.2880

Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.

Publication TypeJournal Article
Year of Publication2011
AuthorsHalassa, MM, Siegle, JH, Ritt, JT, Ting, JT, Feng, G, Moore, CI
JournalNat Neurosci
Volume14
Issue9
Pages1118-20
Date Published2011 Jul 24
ISSN1546-1726
KeywordsAction Potentials, Animals, Bacterial Proteins, Brain Mapping, Electroencephalography, Electromyography, Evoked Potentials, Somatosensory, Glutamate Decarboxylase, Imaging, Three-Dimensional, Light, Luminescent Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Neural Pathways, Neurons, Optical Devices, Patch-Clamp Techniques, Rhodopsin, Somatosensory Cortex, Thalamic Nuclei, Vesicular Inhibitory Amino Acid Transport Proteins
Abstract

The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.

DOI10.1038/nn.2880
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21785436?dopt=Abstract

Alternate JournalNat. Neurosci.
PubMed ID21785436
PubMed Central IDPMC4169194
Grant ListR01 NS045130 / NS / NINDS NIH HHS / United States
R01 NS045130-05A2 / NS / NINDS NIH HHS / United States
R25 MH094612 / MH / NIMH NIH HHS / United States
R01 NS045130-05 / NS / NINDS NIH HHS / United States