Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles.

Nat Neurosci
Authors
Keywords
Abstract

The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.

Year of Publication
2011
Journal
Nat Neurosci
Volume
14
Issue
9
Pages
1118-20
Date Published
2011 Jul 24
ISSN
1546-1726
DOI
10.1038/nn.2880
PubMed ID
21785436
PubMed Central ID
PMC4169194
Links
Grant list
R01 NS045130 / NS / NINDS NIH HHS / United States
R01 NS045130-05A2 / NS / NINDS NIH HHS / United States
R25 MH094612 / MH / NIMH NIH HHS / United States
R01 NS045130-05 / NS / NINDS NIH HHS / United States