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Curr Opin Neurobiol DOI:10.1016/j.conb.2012.02.015

Cellular and synaptic network defects in autism.

Publication TypeJournal Article
Year of Publication2012
AuthorsPeça, J, Feng, G
JournalCurr Opin Neurobiol
Volume22
Issue5
Pages866-72
Date Published2012 Oct
ISSN1873-6882
KeywordsAutistic Disorder, Brain, Humans, Nerve Net, Synapses
Abstract

Many candidate genes are now thought to confer susceptibility to autism spectrum disorders (ASDs). Here we review four interrelated complexes, each composed of multiple families of genes that functionally coalesce on common cellular pathways. We illustrate a common thread in the organization of glutamatergic synapses and suggest a link between genes involved in Tuberous Sclerosis Complex, Fragile X syndrome, Angelman syndrome and several synaptic ASD candidate genes. When viewed in this context, progress in deciphering the molecular architecture of cellular protein-protein interactions together with the unraveling of synaptic dysfunction in neural networks may prove pivotal to advancing our understanding of ASDs.

DOI10.1016/j.conb.2012.02.015
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22440525?dopt=Abstract

Alternate JournalCurr. Opin. Neurobiol.
PubMed ID22440525
PubMed Central IDPMC3407823
Grant ListR01 MH081201 / MH / NIMH NIH HHS / United States
R01 MH081201-05 / MH / NIMH NIH HHS / United States
R01MH081201 / MH / NIMH NIH HHS / United States