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Muscle Nerve DOI:10.1002/mus.23696

Optical inhibition of motor nerve and muscle activity in vivo.

Publication TypeJournal Article
Year of Publication2013
AuthorsLiske, H, Towne, C, Anikeeva, P, Zhao, S, Feng, G, Deisseroth, K, Delp, S
JournalMuscle Nerve
Volume47
Issue6
Pages916-21
Date Published2013 Jun
ISSN1097-4598
KeywordsAnimals, Disease Models, Animal, Electric Stimulation, Electromyography, Halorhodopsins, Mice, Mice, Transgenic, Motor Neurons, Muscle Spasticity, Muscle, Skeletal, Neural Inhibition, Optogenetics, Sciatic Nerve
Abstract

INTRODUCTION: There is no therapeutic approach that provides precise and rapidly reversible inhibition of motor nerve and muscle activity for treatment of spastic hypertonia.

METHODS: We used optogenetics to demonstrate precise and rapidly reversible light-mediated inhibition of motor nerve and muscle activity in vivo in transgenic Thy1::eNpHR2.0 mice.

RESULTS: We found optical inhibition of motor nerve and muscle activity to be effective at all muscle force amplitudes and determined that muscle activity can be modulated by changing light pulse duration and light power density.

CONCLUSIONS: This demonstration of optical inhibition of motor nerves is an important advancement toward novel optogenetics-based therapies for spastic hypertonia.

DOI10.1002/mus.23696
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23629741?dopt=Abstract

Alternate JournalMuscle Nerve
PubMed ID23629741
PubMed Central IDPMC5507203
Grant ListR01 NS080954 / NS / NINDS NIH HHS / United States
R01NS080954 / NS / NINDS NIH HHS / United States