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Nat Neurosci DOI:10.1038/nn.3552

Fast modulation of visual perception by basal forebrain cholinergic neurons.

Publication TypeJournal Article
Year of Publication2013
AuthorsPinto, L, Goard, MJ, Estandian, D, Xu, M, Kwan, AC, Lee, S-H, Harrison, TC, Feng, G, Dan, Y
JournalNat Neurosci
Volume16
Issue12
Pages1857-1863
Date Published2013 Dec
ISSN1546-1726
KeywordsAcetylcholine, Action Potentials, Animals, Archaeal Proteins, Cholera Toxin, Choline O-Acetyltransferase, Cholinergic Neurons, Exercise Test, Glutamate Decarboxylase, Halorhodopsins, Luminescent Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Photic Stimulation, Prosencephalon, Rhodopsin, RNA, Untranslated, Visual Perception
Abstract

The basal forebrain provides the primary source of cholinergic input to the cortex, and it has a crucial function in promoting wakefulness and arousal. However, whether rapid changes in basal forebrain neuron spiking in awake animals can dynamically influence sensory perception is unclear. Here we show that basal forebrain cholinergic neurons rapidly regulate cortical activity and visual perception in awake, behaving mice. Optogenetic activation of the cholinergic neurons or their V1 axon terminals improved performance of a visual discrimination task on a trial-by-trial basis. In V1, basal forebrain activation enhanced visual responses and desynchronized neuronal spiking; these changes could partly account for the behavioral improvement. Conversely, optogenetic basal forebrain inactivation decreased behavioral performance, synchronized cortical activity and impaired visual responses, indicating the importance of cholinergic activity in normal visual processing. These results underscore the causal role of basal forebrain cholinergic neurons in fast, bidirectional modulation of cortical processing and sensory perception.

DOI10.1038/nn.3552
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24162654?dopt=Abstract

Alternate JournalNat. Neurosci.
PubMed ID24162654
PubMed Central IDPMC4201942
Grant ListF31 NS059258 / NS / NINDS NIH HHS / United States
RC1 MH088434 / MH / NIMH NIH HHS / United States
F31 NS084696 / NS / NINDS NIH HHS / United States
F31NS059258 / NS / NINDS NIH HHS / United States
R01 EY018861 / EY / NEI NIH HHS / United States
RC1-MH088434 / MH / NIMH NIH HHS / United States