Next-generation transgenic mice for optogenetic analysis of neural circuits.

Front Neural Circuits
Authors
Keywords
Abstract

Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.

Year of Publication
2013
Journal
Front Neural Circuits
Volume
7
Pages
160
Date Published
2013
ISSN
1662-5110
DOI
10.3389/fncir.2013.00160
PubMed ID
24324405
PubMed Central ID
PMC3840435
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