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Front Neural Circuits DOI:10.3389/fncir.2013.00160

Next-generation transgenic mice for optogenetic analysis of neural circuits.

Publication TypeJournal Article
Year of Publication2013
AuthorsAsrican, B, Augustine, GJ, Berglund, K, Chen, S, Chow, N, Deisseroth, K, Feng, G, Gloss, B, Hira, R, Hoffmann, C, Kasai, H, Katarya, M, Kim, J, Kudolo, J, Lee, LMing, Lo, SQiang, Mancuso, J, Matsuzaki, M, Nakajima, R, Qiu, L, Tan, G, Tang, Y, Ting, JT, Tsuda, S, Wen, L, Zhang, X, Zhao, S
JournalFront Neural Circuits
Date Published2013
KeywordsAction Potentials, Animals, Mice, Mice, Transgenic, Nerve Net, Neural Pathways, Neurons, Optogenetics, Rhodopsin

Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.


Alternate JournalFront Neural Circuits
PubMed ID24324405
PubMed Central IDPMC3840435