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Curr Opin Neurobiol DOI:10.1016/j.conb.2014.08.008

Striatal circuits, habits, and implications for obsessive-compulsive disorder.

Publication TypeJournal Article
Year of Publication2015
AuthorsBurguière, E, Monteiro, P, Mallet, L, Feng, G, Graybiel, AM
JournalCurr Opin Neurobiol
Date Published2015 Feb
KeywordsCorpus Striatum, Habits, Humans, Nerve Net, Neural Pathways, Obsessive-Compulsive Disorder

Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.


Alternate JournalCurr. Opin. Neurobiol.
PubMed ID25241072
PubMed Central IDPMC4293232
Grant ListR01 MH081201 / MH / NIMH NIH HHS / United States
R01 MH097104 / MH / NIMH NIH HHS / United States
R37 HD028341 / HD / NICHD NIH HHS / United States