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Stem Cell Reports DOI:10.1016/j.stemcr.2015.10.011

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Publication TypeJournal Article
Year of Publication2015
AuthorsBrennand, KJ, M Marchetto, C, Benvenisty, N, Brüstle, O, Ebert, A, Belmonte, JCarlos Izp, Kaykas, A, Lancaster, MA, Livesey, FJ, McConnell, MJ, McKay, RD, Morrow, EM, Muotri, AR, Panchision, DM, Rubin, LL, Sawa, A, Soldner, F, Song, H, Studer, L, Temple, S, Vaccarino, FM, Wu, J, Vanderhaeghen, P, Gage, FH, Jaenisch, R
JournalStem Cell Reports
Volume5
Issue6
Pages933-945
Date Published2015 Dec 08
ISSN2213-6711
KeywordsBrain, Brain Diseases, Drug Discovery, Humans, Induced Pluripotent Stem Cells, Mosaicism, Neurogenesis, Precision Medicine
Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

DOI10.1016/j.stemcr.2015.10.011
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26610635?dopt=Abstract

Alternate JournalStem Cell Reports
PubMed ID26610635
PubMed Central IDPMC4881284
Grant ListR01 MH095741 / MH / NIMH NIH HHS / United States
P50 MH094268 / MH / NIMH NIH HHS / United States
P01 NS066888 / NS / NINDS NIH HHS / United States
R33MH087874 / MH / NIMH NIH HHS / United States
U19MH107367 / MH / NIMH NIH HHS / United States
R01MH101454 / MH / NIMH NIH HHS / United States
R01 MH104610 / MH / NIMH NIH HHS / United States
MC_UP_1201/9 / / Medical Research Council / United Kingdom
U01 MH103365 / MH / NIMH NIH HHS / United States
R01 MH103134 / MH / NIMH NIH HHS / United States
R21 MH087879 / MH / NIMH NIH HHS / United States
R01MH105442 / MH / NIMH NIH HHS / United States
R01MH089176 / MH / NIMH NIH HHS / United States
101052 / / Wellcome Trust / United Kingdom
R33 MH087874 / MH / NIMH NIH HHS / United States
R01 MH105660 / MH / NIMH NIH HHS / United States
R21MH087879 / MH / NIMH NIH HHS / United States
R01 MH094753 / MH / NIMH NIH HHS / United States
R01MH105660 / MH / NIMH NIH HHS / United States
P50MH094268 / MH / NIMH NIH HHS / United States
R01 NS088538 / NS / NINDS NIH HHS / United States
R01 MH102418 / MH / NIMH NIH HHS / United States
R01NS047344 / NS / NINDS NIH HHS / United States
R01NS088538 / NS / NINDS NIH HHS / United States
R01MH102418 / MH / NIMH NIH HHS / United States
R01MH095741 / MH / NIMH NIH HHS / United States
R01 MH101454 / MH / NIMH NIH HHS / United States
P01NS066888 / NS / NINDS NIH HHS / United States
R01MH092443 / MH / NIMH NIH HHS / United States
R01 NS047344 / NS / NINDS NIH HHS / United States
R01 MH105442 / MH / NIMH NIH HHS / United States
U01MH1068821 / MH / NIMH NIH HHS / United States
RF1AG042932 / AG / NIA NIH HHS / United States
R01 MH092443 / MH / NIMH NIH HHS / United States
RF1 AG042932 / AG / NIA NIH HHS / United States
R01 MH089176 / MH / NIMH NIH HHS / United States
U19 MH107367 / MH / NIMH NIH HHS / United States
R01MH103134 / MH / NIMH NIH HHS / United States
R01MH094753 / MH / NIMH NIH HHS / United States
/ / Wellcome Trust / United Kingdom
2R01MH104610 / MH / NIMH NIH HHS / United States
P30 CA014195 / CA / NCI NIH HHS / United States