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Science DOI:10.1126/science.1239882

Development-inspired reprogramming of the mammalian central nervous system.

Publication TypeJournal Article
Year of Publication2014
AuthorsAmamoto, R, Arlotta, P
JournalScience
Volume343
Issue6170
Pages1239882
Date Published2014 Jan 31
ISSN1095-9203
KeywordsAnimals, Astrocytes, Cell Lineage, Cellular Reprogramming, Central Nervous System, Fibroblasts, Hepatocytes, Humans, Mammals, Mitosis, Neurogenesis, Neurons, Transcription Factors
Abstract

In 2012, John Gurdon and Shinya Yamanaka shared the Nobel Prize for the demonstration that the identity of differentiated cells is not irreversibly determined but can be changed back to a pluripotent state under appropriate instructive signals. The principle that differentiated cells can revert to an embryonic state and even be converted directly from one cell type into another not only turns fundamental principles of development on their heads but also has profound implications for regenerative medicine. Replacement of diseased tissue with newly reprogrammed cells and modeling of human disease are concrete opportunities. Here, we focus on the central nervous system to consider whether and how reprogramming of cell identity may affect regeneration and modeling of a system historically considered immutable and hardwired.

DOI10.1126/science.1239882
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/24482482?dopt=Abstract

Alternate JournalScience
PubMed ID24482482
PubMed Central IDPMC4122114
Grant ListR01 NS062849 / NS / NINDS NIH HHS / United States
T32 GM007226 / GM / NIGMS NIH HHS / United States