Development-inspired reprogramming of the mammalian central nervous system.

Science
Authors
Keywords
Abstract

In 2012, John Gurdon and Shinya Yamanaka shared the Nobel Prize for the demonstration that the identity of differentiated cells is not irreversibly determined but can be changed back to a pluripotent state under appropriate instructive signals. The principle that differentiated cells can revert to an embryonic state and even be converted directly from one cell type into another not only turns fundamental principles of development on their heads but also has profound implications for regenerative medicine. Replacement of diseased tissue with newly reprogrammed cells and modeling of human disease are concrete opportunities. Here, we focus on the central nervous system to consider whether and how reprogramming of cell identity may affect regeneration and modeling of a system historically considered immutable and hardwired.

Year of Publication
2014
Journal
Science
Volume
343
Issue
6170
Pages
1239882
Date Published
2014 Jan 31
ISSN
1095-9203
DOI
10.1126/science.1239882
PubMed ID
24482482
PubMed Central ID
PMC4122114
Links
Grant list
R01 NS062849 / NS / NINDS NIH HHS / United States
T32 GM007226 / GM / NIGMS NIH HHS / United States