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Trends Neurosci DOI:10.1016/j.tins.2014.11.003

Cerebral cortex assembly: generating and reprogramming projection neuron diversity.

Publication TypeJournal Article
Year of Publication2015
AuthorsLodato, S, Shetty, AS, Arlotta, P
JournalTrends Neurosci
Date Published2015 Feb
KeywordsAnimals, Cerebral Cortex, Humans, Interneurons, Nerve Net, Neurogenesis, Neuronal Plasticity, Neurons

The mammalian cerebral cortex is responsible for the highest levels of associative, cognitive and motor functions. In the central nervous system (CNS) the cortex stands as a prime example of extreme neuronal diversity, broadly classified into excitatory projection neurons (PNs) and inhibitory interneurons (INs). We review here recent progress made in understanding the strategies and mechanisms that shape PN diversity during embryogenesis, and discuss how PN classes may be maintained, postnatally, for the life of the organism. In addition, we consider the intriguing possibility that PNs may be amenable to directed reprogramming of their class-specific features to allow enhanced cortical plasticity in the adult.


Alternate JournalTrends Neurosci.
PubMed ID25529141
PubMed Central IDPMC4334136
Grant ListR01 MH101268 / MH / NIMH NIH HHS / United States
R01 NS062849 / NS / NINDS NIH HHS / United States
MH101268 / MH / NIMH NIH HHS / United States
NS062849 / NS / NINDS NIH HHS / United States