You are here

Wiley Interdiscip Rev Dev Biol DOI:10.1002/wdev.192

Building blocks of the cerebral cortex: from development to the dish.

Publication TypeJournal Article
Year of Publication2015
AuthorsHarris, J, Tomassy, GSrubek, Arlotta, P
JournalWiley Interdiscip Rev Dev Biol
Date Published2015 Sep-Oct
KeywordsAnimals, Cerebral Cortex, Humans, Neural Stem Cells, Neurogenesis, Neurons

Since Ramon y Cajal's examination of the cellular makeup of the cerebral cortex, it has been appreciated that this tissue exhibits some of the greatest degrees of cellular heterogeneity in the entire nervous system. This intricate structure emerges during a well-choreographed developmental process. Here, we review current classifications of the cellular constituents of the cerebral cortex and examine how these building blocks are forged during development. We also look at how basic developmental features underlying cortex formation in vivo have been applied to protocols aimed at generating cortical tissue in vitro.


Alternate JournalWiley Interdiscip Rev Dev Biol
PubMed ID25926310
PubMed Central IDPMC4529802
Grant ListT32 GM007753 / GM / NIGMS NIH HHS / United States
T32GM007753 / GM / NIGMS NIH HHS / United States