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Annu Rev Cell Dev Biol DOI:10.1146/annurev-cellbio-100814-125353

Generating neuronal diversity in the mammalian cerebral cortex.

Publication TypeJournal Article
Year of Publication2015
AuthorsLodato, S, Arlotta, P
JournalAnnu Rev Cell Dev Biol
Date Published2015
KeywordsAnimals, Biological Evolution, Humans, Mammals, Neocortex, Nerve Net, Neurons

The neocortex is the part of the brain responsible for execution of higher-order brain functions, including cognition, sensory perception, and sophisticated motor control. During evolution, the neocortex has developed an unparalleled neuronal diversity, which still remains partly unclassified and unmapped at the functional level. Here, we broadly review the structural blueprint of the neocortex and discuss the current classification of its neuronal diversity. We then cover the principles and mechanisms that build neuronal diversity during cortical development and consider the impact of neuronal class-specific identity in shaping cortical connectivity and function.


Alternate JournalAnnu. Rev. Cell Dev. Biol.
PubMed ID26359774
PubMed Central IDPMC4778709
Grant ListR01 NS062849 / NS / NINDS NIH HHS / United States