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Trends Neurosci DOI:10.1016/j.tins.2015.10.005

Homeotic Transformations of Neuronal Cell Identities.

Publication TypeJournal Article
Year of Publication2015
AuthorsArlotta, P, Hobert, O
JournalTrends Neurosci
Date Published2015 Dec
KeywordsAnimals, Animals, Genetically Modified, Biological Evolution, Brain, Humans, Morphogenesis, Neurons, Plants

Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.


Alternate JournalTrends Neurosci.
PubMed ID26596501
Grant ListR01MH101268 / MH / NIMH NIH HHS / United States
R01NS078164 / NS / NINDS NIH HHS / United States
R37NS039996 / NS / NINDS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States