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Nat Med DOI:10.1038/nm.4214

The promises and challenges of human brain organoids as models of neuropsychiatric disease.

Publication TypeJournal Article
Year of Publication2016
AuthorsQuadrato, G, Brown, J, Arlotta, P
JournalNat Med
Date Published2016 Nov
KeywordsAutism Spectrum Disorder, Bipolar Disorder, Brain, Humans, In Vitro Techniques, Induced Pluripotent Stem Cells, Mental Disorders, Models, Neurological, Models, Psychological, Nerve Net, Neurogenesis, Organoids, Pluripotent Stem Cells, Schizophrenia

Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ) and bipolar disorder (BPD) are of great societal and medical importance, but the complexity of these diseases and the challenges of modeling the development and function of the human brain have made these disorders difficult to study experimentally. The recent development of 3D brain organoids derived from human pluripotent stem cells offers a promising approach for investigating the phenotypic underpinnings of these highly polygenic disorders and for understanding the contribution of individual risk variants and complex genetic background to human pathology. Here we discuss the advantages, limitations and future applications of human brain organoids as in vitro models of neuropsychiatric disease.


Alternate JournalNat. Med.
PubMed ID27783065