Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.
J Neurosci
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Abstract | Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with endogenous spinal motoneurons or embryonic stem cell-derived motoneurons (ESCMNs). In the present study, we first used a proteomic approach and compared protein expression profiles between iPSCMNs and ESCMNs to show that |
Year of Publication | 2015
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Journal | J Neurosci
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Volume | 35
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Issue | 3
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Pages | 1291-306
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Date Published | 2015 Jan 21
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ISSN | 1529-2401
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DOI | 10.1523/JNEUROSCI.2126-14.2015
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PubMed ID | 25609642
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PubMed Central ID | PMC4402330
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Grant list | R00 NS077435 / NS / NINDS NIH HHS / United States
Canadian Institutes of Health Research / Canada
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