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J Neurosci DOI:10.1523/JNEUROSCI.2126-14.2015

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.

Publication TypeJournal Article
Year of Publication2015
AuthorsToma, JS, Shettar, BC, Chipman, PH, Pinto, DM, Borowska, JP, Ichida, JK, Fawcett, JP, Zhang, Y, Eggan, K, Rafuse, VF
JournalJ Neurosci
Volume35
Issue3
Pages1291-306
Date Published2015 Jan 21
ISSN1529-2401
KeywordsAnimals, Axons, Chick Embryo, Induced Pluripotent Stem Cells, LIM-Homeodomain Proteins, Mice, Motor Neurons, Muscle, Skeletal, Neurogenesis, Neuromuscular Junction, Phenotype, Proteomics, Transcription Factors
Abstract

Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with endogenous spinal motoneurons or embryonic stem cell-derived motoneurons (ESCMNs). In the present study, we first used a proteomic approach and compared protein expression profiles between iPSCMNs and ESCMNs to show that

DOI10.1523/JNEUROSCI.2126-14.2015
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25609642?dopt=Abstract

Alternate JournalJ. Neurosci.
PubMed ID25609642
PubMed Central IDPMC4402330
Grant ListR00 NS077435 / NS / NINDS NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada