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Stem Cell Reports DOI:10.1016/j.stemcr.2017.05.029

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.

Publication TypeJournal Article
Year of Publication2017
AuthorsAndrews, PW, Ben-David, U, Benvenisty, N, Coffey, P, Eggan, K, Knowles, BB, Nagy, A, Pera, M, Reubinoff, B, Rugg-Gunn, PJ, Stacey, GN
JournalStem Cell Reports
Date Published2017 07 11
KeywordsCytogenetic Analysis, Epigenesis, Genetic, Genetic Variation, Humans, Maine, Pluripotent Stem Cells, Regenerative Medicine, Risk Assessment

Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the safety of therapeutic applications of these cells can be assessed. A strong recommendation from the meeting was that an international advisory group should be set up to review the genetic and epigenetic changes observed in human pluripotent stem cell lines and establish a framework for evaluating the risks that they may pose for clinical use.


Alternate JournalStem Cell Reports
PubMed ID28700896
Grant ListMR/L012537/1 / / Medical Research Council / United Kingdom