Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
Nature
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Abstract | Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P |
Year of Publication | 2017
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Journal | Nature
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Volume | 541
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Issue | 7635
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Pages | 81-86
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Date Published | 2017 Jan 05
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ISSN | 1476-4687
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DOI | 10.1038/nature20784
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PubMed ID | 28002404
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