Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex.
Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of the myelin envelope is a structural feature affecting the conduction of neuronal signals. Conversely, the distribution of myelinated tracts along the length of axons has been assumed to be uniform. Here, we traced high-throughput electron microscopy reconstructions of single axons of pyramidal neurons in the mouse neocortex and built high-resolution maps of myelination. We find that individual neurons have distinct longitudinal distribution of myelin. Neurons in the superficial layers displayed the most diversified profiles, including a new pattern where myelinated segments are interspersed with long, unmyelinated tracts. Our data indicate that the profile of longitudinal distribution of myelin is an integral feature of neuronal identity and may have evolved as a strategy to modulate long-distance communication in the neocortex.
|Year of Publication||
2014 Apr 18
|PubMed Central ID||
1P50MH094271 / MH / NIMH NIH HHS / United States
NS062849 / NS / NINDS NIH HHS / United States
NS078164 / NS / NINDS NIH HHS / United States
P50 MH094271 / MH / NIMH NIH HHS / United States
R01 EB016411 / EB / NIBIB NIH HHS / United States
R01 NS062849 / NS / NINDS NIH HHS / United States
R01 NS078164 / NS / NINDS NIH HHS / United States
Howard Hughes Medical Institute / United States